Overview

The central theme of the Molander group’s research is the development of new synthetic methods and their application to the synthesis of organic molecules. The group’s focus centers on catalysis, specifically using robust, air- and water-stable potassium organotrifluoroborates (R-BF3K) as partners in cross-coupling. To this end, we have recently engaged a new strategy involving a photoredox-based oxidation of organotrifluoroborates resulting in radicals that can be effectively funneled into a cross coupling catalytic cycle. Additionally we are exploring the unique chemistry of these boron-based salts and their application towards the synthesis of boron-containing heterocycles known as azaborines. We have also been exploring organofluorine chemistry as well as reductive cross-coupling. These four areas of research are detailed below: