Christopher Kelly

Postdoctoral Researcher


Education:

  University of Pennsylvania, 2015-present
Postdoctoral Researcher with Professor Gary A. Molander

Ph.D. University of Connecticut, 2015
"Advances in Organofluorine Chemistry, Novel Oxoammonium-Cation Mediated Transformations, and the Utilization of Emerging Technologies for Organic Reactions" with Prof. Nicholas E. Leadbeater

B.S. Stonehill College, 2010
with Prof. Leon J. Tilley
Current Research:
    Photoredox Cross-Coupling

Publications:
  • Mild, Redox-Neutral Alkylation of Imines Enabled by an Organic Photocatalyst LPatel, N. R.; Kelly, C. B.; Siegenfeld, A. P.; Molander, G. A. ACS Catal. 2017, 7, 1766.
  • Preparation of visible-light-activated metal complexes and their use in photoredox/nickel dual catalysis Kelly, C. B.; Patel, N. R.; Primer, D. N.; Jouffroy, M.; Tellis, J. C.; Molander, G. A. Nat. Protoc. 2017, 12, 472.
  • Preparation of diisopropylammonium bis(catecholato)cyclohexylsilicate Lin, K.; Kelly, C. B.; Jouffroy, M.; Molander, G. A. Org. Synth. 2017, 94, 16.
  • Oxidative Cleavage of Silyl Ethers by an Oxoammonium Salt Loman, J. J.; Pistritto, V. A.; Kelly, C. B.; Leadbeater, N. E. Synlett 2016, 27, 2372.
  • Single-Electron Transmetalation via Photoredox/Nickel Dual Catalysis: Unlocking a New Paradigm for sp3–sp2 Cross-Coupling Tellis, J. C.; Kelly, C. B.; Primer, D. N.; Jouffroy, M.; Patel, N. R.; Molander, G. A. Acc. Chem. Res. 2016, 49. 1429.
  • A combined computational and experimental investigation of the oxidative ring-opening of cyclic ethers by oxoammonium cations Loman, J. J.; Carnaghan, E. R.; Hamlin, T. A.; Ovian, J. M.; Kelly, C. B.; Mercadante, M. A.; Leadbeater, N. E. Org. Biomol. Chem. 2016, 14, 3883.
  • Thioetherification via Photoredox/Nickel Dual Catalysis Jouffroy, M.; Kelly, C. B.; Molander, G. A. Org. Lett. 2016, 18, 876.
  • Engaging Alkenyl Halides with Alkylsilicates via Photoredox Dual Catalysis Patel, N. R..; Kelly, C. B.; Jouffroy, M.; Molander, G. A. Org. Lett. 2016, 18, 764.
  • Towards a Unified Mechanism for Oxoammonium Salt-Mediated Oxidation Reactions: A Theoretical and Experimental Study Using a Hydride Transfer Model Hamlin, T. A.; Kelly, C. B.; Ovian, J. M.; Wiles, R. J.; Tilley, L. J.; Leadbeater, N. E. J. Org. Chem. 2015, 80, 8150.
  • Synthesis of Perfluoroalkyl-Substituted Vinylcyclopropanes by Way of Enhanced Neighboring Group Participation Kelly, C. B.; M. A. Mercadante, Carnaghan, E. R.; Doherty, M. J.; Fager, D. C.; Hauck, J. J.; MacInnis, A. E.; Tilley, L. J.; Leadbeater, N. E. Eur. J. Org. Chem. 2015, 10601.
  • Oxidative Cleavage of Allyl Ethers by an Oxoammonium Salt Kelly, C. B.; Ovian, J. M.; Cywar, R. M.; Gossland, T. R.; Wiles, R. J.; Leadbeater, N. E.Org. Biomol. Chem. 2015, 13, 4255.
  • Access to Nitriles from Aldehydes Mediated by an Oxoammonium Salt Kelly, C. B.; Lambert, K. M.; Mercadante, M. A.; Ovian, J. M.; Bailey, W. F.; Leadbeater, N. E. Angew. Chem. Int. Ed., 2015, 54, 4241.
  • A Continuous-Flow Approach to 3,3,3-Trifluoromethylpropenes: Bringing Together Grignard Addition, Peterson Elimination, Inline Extraction, and Solvent Switching. Hamlin, T. A.; Lazarus, G. M. L.; Kelly, C. B.; Leadbeater, N. E.Org. Process Res. Dev. 2015, 14, 4862.
  • 1,3-γ-Silyl-elimination in electron-deficient cationic systems Mercadante, M. A.; Kelly, C. B.; Leadbeater, N. E.; Tilley L. J et al. Chem. Sci., 2014, 5, 3983.
  • A Scalable and Regioselective Synthesis of 2-Difluoromethyl Pyridines from Commodity Chemicals Desrosiers, J.-N.; Kelly, C. B.; Fandrick, D.; Song, J.; Senanayake, C. et al. Org. Lett., 2014, 16, 1724.
  • Methylenation of Perfluoroalkyl Ketones using a Peterson Olefination Approach Hamlin, T. A.; Kelly, C. B.; Cywar, R. M.; Leadbeater, N. E.J. Org. Chem., 2014, 79, 1145.
  • Oxoammonium Salt Oxidations of Alcohols in the Presence of Pyridine Bases Bobbitt, J. M.; Bartelson, A. L.; Bailey, W. F.; Hamlin, T. A.; Kelly, C. B. J. Org. Chem., 2014, 79, 1055.
  • Trifluoromethyl ketones: properties, preparation, and application Kelly, C. B.; Mercadante, M. A.; Leadbeater, N. E. Chem. Commun., 2013, 49, 11133.
  • Oxidative Esterification of Aldehydes via an Oxoammonium Salt Kelly, C. B.; Mercadante, M. A.; Wiles, R. J.; Leadbeater, N. E. Org. Lett., 2013, 15, 2222.
  • Dehydrogenation of Perfluoroalkyl Ketones Using a Recyclable Oxoammonium Salt Hamlin, T. A.; Kelly, C. B.; Leadbeater, N. E. Eur. J. Org. Chem., 2013, 3658.
  • Synthesis of 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate and 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl and their use in oxidative reactions Mercadante, M. A.; Kelly, C. B.; Bobbitt, J. M.; Tilley, L. J.; Leadbeater, N. E. Nat. Protoc., 2013, 8, 666.
  • 2,2,6,6-Tetramethylpiperidine-Based Oxoammonium Salts Kelly, C.B. Synlett Spotlight No. 423, 2013, 24, 527.
  • Oxidation of α-Trifluoromethyl Alcohols Using a Recyclable Oxoammonium Salt Kelly, C. B.; Mercadante, M. A.; Hamlin, T. A.; Fletcher, M. H.; Leadbeater, N. E. J. Org. Chem., 2012, 77, 8131.
  • A Weinreb amide approach to the synthesis of trifluoromethylketones Rudzinski, D. M.; Kelly C. B.; Leadbeater, N. E Chem. Commun., 2012, 48, 9610.
  • Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor Mercadante, M. A.; Kelly, C. B.; Lee, C.; Leadbeater, N. E. Org. Process. Res. Dev., 2012, 16, 1064.
  • Access to Dienophilic Ene-Triketone Synthons by Oxidation of Diketones with an Oxoammonium Salt Eddy, N. A.; Kelly, C.B.; Mercadante, M. A.; Leadbeater, N. E.; Fenteany, G. Org. Lett., 2012, 14, 498.
  • Copper-catalyzed direct preparation of diaryl sulfides from aryl iodides using potassium thiocyanate as a sulfur transfer reagent Kelly, C. B.; Lee, C.; Leadbeater, N. E.Tetrahedron Lett., 2011, 52, 4587.
  • A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions Kelly, C. B.; Lee, C.; Mercadante, M. A.; Leadbeater, N. E.Org. Process Res. Dev., 2011, 15, 717.
  • Enabling the Synthesis of Perfluoroalkyl Bicyclobutanes via 1,3 γ-Silyl Elimination Kelly, C. B.; Tilley, L. J. et al.Org. Lett., 2011, 13, 1646.
  • An approach for continuous-flow processing of reactions that involve the in situ formation of organic products Kelly, C. B.; Lee, C.; Leadbeater N. E. Tetrahedron Lett., 2010, 52, 263.